![]() ![]() Magnetic field application increases the action, likely via enhanced diffusion of the iron-oxide NPs and NP-drug conjugates through mucin and alginate barriers, which are characteristic of cystic-fibrosis respiratory infections. ![]() Our findings suggest that the alginate-coated nanocomposites investigated in this study have the potential to overcome the bacterial biofilm barrier. We report zero susceptibility to iron-oxide NPs capped with polyethylene glycol, suggesting that the capping agent plays a major role in enabling bactericidal ability in of the nanocomposite. Positive inhibition is reported for uncapped and alginate-capped iron-oxide NPs, and the corresponding MICs are presented. MIC of all compounds of interest was determined after 60-days of growth, to ensure thorough establishment of biofilm colonies. Investigations into susceptibility using the disk diffusion method were done after 3 days of biofilm growth and after 60 days of growth. Susceptibility and minimum inhibitory concentration (MIC) of the NPs, NP-tobramycin conjugates, and tobramycin alone were determined in the PAO1 bacterial colonies. We also investigated alginate-capped iron-oxide NP-drug conjugates, with a practically unchanged hydrodynamic diameter of ~ 232 nm. Alginate capping increased the average hydrodynamic diameter to ~ 230 nm. We report bacterial inhibition by iron-oxide (nominally magnetite) nanoparticles (NPs) alone, having a mean hydrodynamic diameter of ~ 16 nm, as well as alginate-capped iron-oxide NPs. aeruginosa infection still eludes investigators, despite the extensive research in this area. Due to the ubiquity and high adaptability of this species, an effective universal treatment method for P. aeruginosa is the primary Gram-negative etiology responsible for nosocomial infections. Being the most common infectious species of the Pseudomonas genus, P. Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. From this work, the potential of synchrotron radiation to complement conventional characterization techniques in the investigation of nanoparticles for high density recording and biomedical applications is underlined. The other reaction with a reducing agent gave rise to smaller nanoparticles of two size distributions. Nanoparticles synthesized by using a higher amount of Fe(acac)3 were matched with monodisperse spheres of radius 2.4☐.3 nm. The measured SAXS intensity profiles as a function of the scattering vector from 0.27 to 2.30 nm-1 were fitted and compared between two different reactions. In small-angle X-ray scattering (SAXS) measurements at the Synchrotron Light Research Institute, Thailand, each magnetic fluid was injected into a sample cell with aluminum foil windows and the X-ray of wavelength 1.55 Å from BL2.2 was used. The starting material was an environmental friendly iron(III) acetylacetonate and the products were dispersed in n-hexane. In this work, iron-platinum (FePt) nanoparticles with their surface modified by oleic acid and oleyleamine were synthesized from the polyol process. Before their assembly into patterned media, the as-synthesized FePt nanoparticles in superparamagnetic state are commonly stored in forms of magnetic fluids. On the other hand, iron-platinum (FePt) is investigated as materials for ultrahigh density recording. In addition to the conventional uses in mechanical engineering, magnetic fluids containing magnetite (Fe3O4) superparamagnetic nanoparticles are under research and development for drug delivery, hyperthermia and MRI contrast agents. Magnetic fluid is a special class of materials which possesses the advantages of a liquid state of the carrier and a magnetic state of the particles. ![]()
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